/* The four paid tools: analysis plan, evidence table, response to reviewers, systematic review (js/tools.js) */
.tl-grid { display: grid; grid-template-columns: minmax(0, 1.25fr) minmax(0, .75fr); gap: 32px; align-items: start; padding-bottom: 28px; }
@media (max-width: 960px) { .tl-grid { grid-template-columns: minmax(0, 1fr); } }
.tl-side { display: grid; gap: 18px; }
.tl-side h2 { margin: 0 0 8px; font-size: 18px; font-weight: 600; }
.tl-side ol, .tl-side ul { margin: 0; padding-left: 20px; display: grid; gap: 7px; color: var(--ink-2); line-height: 1.55; font-size: 15px; }
.tl-jobs { border: 1px solid var(--line); border-radius: 10px; background: var(--surface); padding: 16px 18px; }
.tl-jobs h2 { font-size: 16px; margin: 0 0 8px; }
.tl-jobs ul { list-style: none; padding: 0; margin: 0 0 8px; display: grid; gap: 8px; }
.tl-jobs li { display: grid; gap: 1px; font-size: 14.5px; }
.tl-jobs li span { color: var(--muted); font-size: 13px; }
.tl-jobs p { margin: 0; font-size: 14px; }
.fld .hint { margin: 0; color: var(--muted); font-size: 13px; }
.chk { display: flex; gap: 10px; align-items: flex-start; font-size: 14.5px; line-height: 1.45; }
.chk input { margin-top: 3px; width: 18px; height: 18px; flex: none; }
.fld-row.three { grid-template-columns: repeat(3, minmax(0, 1fr)); }
@media (max-width: 640px) { .fld-row.three { grid-template-columns: minmax(0, 1fr); } }

/* the variables editor (analysis plan) */
.vars { display: grid; gap: 10px; }
.var-row { display: grid; grid-template-columns: minmax(0, 1.4fr) minmax(0, 1fr) minmax(0, 1fr) minmax(0, 1.2fr) auto auto; gap: 8px; align-items: end; padding: 10px; border: 1px solid var(--line); border-radius: 10px; background: var(--surface-2); }
.var-row label { display: grid; gap: 3px; font-size: 12.5px; color: var(--ink-2); }
.var-row input, .var-row select { min-height: 40px; padding: 0 10px; border: 1px solid var(--line-strong); border-radius: 8px; background: var(--surface); color: var(--ink); font: inherit; font-size: 14px; width: 100%; box-sizing: border-box; }
.var-row .prim { display: flex; align-items: center; gap: 5px; font-size: 12.5px; white-space: nowrap; min-height: 40px; }
.var-row .del { min-height: 40px; padding: 0 10px; border: 1px solid var(--line-strong); border-radius: 8px; background: var(--surface); color: var(--bad); cursor: pointer; font: inherit; }
@media (max-width: 860px) { .var-row { grid-template-columns: minmax(0, 1fr) minmax(0, 1fr); } .var-row label:first-child { grid-column: 1 / -1; } }
.add-var { justify-self: start; }

/* choosing papers (evidence table) */
.papers { max-height: 420px; overflow-y: auto; border: 1px solid var(--line); border-radius: 10px; background: var(--surface); }
.papers label { display: grid; grid-template-columns: auto minmax(0, 1fr); gap: 10px; padding: 10px 12px; border-bottom: 1px solid var(--line); font-size: 14px; line-height: 1.4; cursor: pointer; }
.papers label:last-child { border-bottom: 0; }
.papers label small { display: block; color: var(--muted); font-size: 12.5px; }
.papers input { width: 17px; height: 17px; margin-top: 2px; }
.papers-bar { display: flex; flex-wrap: wrap; gap: 8px 14px; align-items: center; font-size: 14px; color: var(--ink-2); }

/* checkout, run, result */
.tl-box { border: 1px solid var(--line); border-radius: 12px; background: var(--surface); padding: 22px; display: grid; gap: 14px; box-shadow: var(--shadow); margin-bottom: 24px; }
.tl-box h2 { margin: 0; font-size: 20px; }
.tl-co { display: grid; grid-template-columns: minmax(0, 1.1fr) minmax(0, 1fr); gap: 16px; }
@media (max-width: 760px) { .tl-co { grid-template-columns: minmax(0, 1fr); } }
.tl-co > div { padding: 16px 18px; border: 1px solid var(--line); border-radius: 12px; background: var(--surface-2); }
.tl-co h3 { margin: 0 0 8px; font-size: 15px; }
.tl-co ul { margin: 0; padding-left: 20px; display: grid; gap: 5px; font-size: 14.5px; color: var(--ink-2); }
.tl-sum { width: 100%; border-collapse: collapse; font-size: 14.5px; }
.tl-sum td { padding: 6px 0; }
.tl-sum td:last-child { text-align: right; font-variant-numeric: tabular-nums; }
.tl-sum tr.tot td { border-top: 1px solid var(--line); padding-top: 10px; font-weight: 700; font-size: 16px; }
.tl-act { display: flex; flex-wrap: wrap; gap: 10px 14px; align-items: center; }
.tl-act p { margin: 0; color: var(--muted); font-size: 14px; }
.tl-msg { margin: 0; font-size: 14.5px; color: var(--good, #1D7547); }
.tl-msg.bad { color: var(--bad); }
.tl-msg:empty { display: none; }
.tl-steps { list-style: none; margin: 0; padding: 0; display: grid; gap: 6px; font-size: 14.5px; }
.tl-steps li { padding-left: 22px; position: relative; color: var(--ink-2); }
.tl-steps li::before { content: ''; position: absolute; left: 2px; top: 6px; width: 10px; height: 10px; border-radius: 50%; background: var(--line-strong); }
.tl-steps li.on::before { background: var(--accent); animation: tl-pulse 1s ease-in-out infinite; }
.tl-steps li.ok::before { background: var(--good, #1D7547); }
@keyframes tl-pulse { 50% { opacity: .35; } }
@media (prefers-reduced-motion: reduce) { .tl-steps li.on::before { animation: none; } }
.tl-out-bar { position: sticky; top: 0; z-index: 5; display: flex; flex-wrap: wrap; gap: 10px; align-items: center; padding: 12px 0; background: var(--bg, #F7F8FB); }
.tl-checks { margin: 0; font-size: 14px; color: var(--ink-2); }
.tl-doc { padding: 18px 8px 40px; overflow-x: auto; background: #EEF0F4; border-radius: 12px; }

/* document pages (same look as the synopsis view) */
.tl-doc .sheet { display: block; box-sizing: border-box; width: 210mm; max-width: 100%; min-height: 200mm; margin: 0 auto 18px; padding: 22mm 22mm 22mm 28mm; background: #fff; color: #111; box-shadow: 0 2px 10px rgba(0,0,0,.12); font-family: 'Times New Roman', Times, serif; font-size: 12pt; line-height: 1.5; }
.tl-doc .sheet.wide { width: 297mm; min-height: 150mm; padding: 16mm 18mm; }
.tl-doc .sheet p { margin: 0 0 6pt; text-align: justify; }
.tl-doc .sheet h2, .tl-doc .sheet h3 { font-family: inherit; color: #111; letter-spacing: 0; }
.tl-doc .sheet h2 { font-size: 14pt; margin: 12pt 0 8pt; font-weight: 700; }
.tl-doc .sheet h3 { font-size: 12pt; margin: 8pt 0 4pt; font-weight: 700; }
.tl-doc .sheet h2.c, .tl-doc .sheet h3.c { text-align: center; }
.tl-doc .sheet .rule { border-bottom: 1.5px solid #2E5597; padding-bottom: 3pt; }
.tl-doc .sheet ol, .tl-doc .sheet ul { margin: 0 0 6pt; padding-left: 2em; }
.tl-doc .sheet li { margin-bottom: 3pt; }
.tl-doc .sheet table.t { width: 100%; border-collapse: collapse; margin: 6pt 0 10pt; table-layout: fixed; font-size: 10.5pt; line-height: 1.35; }
.tl-doc .sheet.wide table.t { font-size: 9.5pt; }
.tl-doc .sheet table.t td { border: 1px solid #808080; padding: 4pt 5pt; vertical-align: top; overflow-wrap: anywhere; }
.tl-doc .sheet table.t td div { margin-bottom: 3pt; }
.tl-doc .sheet table.t td.head { background: #DCE6F1; font-weight: 700; }
.tl-doc .sheet table.t td.sh-label { background: #F2F2F2; font-family: 'IBM Plex Mono', Consolas, monospace; font-size: 9.5pt; white-space: pre-wrap; }
.tl-doc .sheet table.t td.sh-section { background: #DCE6F1; font-weight: 700; }
@media (max-width: 760px) { .tl-doc .sheet, .tl-doc .sheet.wide { padding: 14px; min-height: 0; font-size: 11pt; } }
@media print { .tl-grid, .tl-box, .tl-out-bar, .page-head, .tl-jobs { display: none !important; } .tl-doc { background: none; padding: 0; } .tl-doc .sheet { box-shadow: none; margin: 0; } }

/* Pharmacovigilance forms (js/adr-form.js, js/adr-register.js) */
.inline2 { display: grid; grid-template-columns: minmax(0, 1fr) auto; gap: 6px; }
.inline2 select { width: auto; }
.chk-grid { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: 6px 14px; }
@media (max-width: 640px) { .chk-grid { grid-template-columns: minmax(0, 1fr); } }
.qgrid { display: grid; gap: 8px; }
.qgrid label { display: grid; grid-template-columns: minmax(0, 1fr) 150px; gap: 10px; align-items: center; font-size: 14.5px; line-height: 1.4; padding: 8px 10px; border: 1px solid var(--line); border-radius: 8px; background: var(--surface-2); }
.qgrid select { min-height: 38px; border: 1px solid var(--line-strong); border-radius: 8px; padding: 0 8px; font: inherit; font-size: 14px; background: var(--surface); color: var(--ink); }
@media (max-width: 560px) { .qgrid label { grid-template-columns: minmax(0, 1fr); } }
.drugs { display: grid; gap: 10px; }
.drug-row { padding: 12px; border: 1px solid var(--line); border-radius: 10px; background: var(--surface-2); display: grid; gap: 8px; }
.drug-row label { display: grid; gap: 3px; font-size: 13px; color: var(--ink-2); }
.drug-row input, .drug-row select { min-height: 40px; padding: 0 10px; border: 1px solid var(--line-strong); border-radius: 8px; background: var(--surface); color: var(--ink); font: inherit; font-size: 14px; width: 100%; box-sizing: border-box; }
.drug-row .del-drug { justify-self: start; color: var(--bad); }
.rg-wrap { overflow-x: auto; border: 1px solid var(--line); border-radius: 10px; max-height: 520px; overflow-y: auto; }
.rg-table { border-collapse: collapse; font-size: 13px; min-width: 1500px; }
.rg-table th { position: sticky; top: 0; background: var(--surface-2); text-align: left; padding: 8px 6px; border-bottom: 1px solid var(--line); white-space: nowrap; z-index: 1; }
.rg-table td { padding: 4px; border-bottom: 1px solid var(--line); vertical-align: top; }
.rg-table td.n { color: var(--muted); text-align: right; padding-top: 12px; }
.rg-table input, .rg-table select { width: 100%; min-width: 80px; min-height: 34px; padding: 0 6px; border: 1px solid var(--line-strong); border-radius: 6px; background: var(--surface); color: var(--ink); font: inherit; font-size: 13px; box-sizing: border-box; }
.rg-table input[data-c="drug"], .rg-table input[data-c="reaction"] { min-width: 170px; }
.rg-table select[data-c="soc"] { min-width: 170px; }
.rg-table .del { min-height: 34px; padding: 0 9px; border: 1px solid var(--line-strong); border-radius: 6px; background: var(--surface); color: var(--bad); cursor: pointer; }
/* Genomics: genotype counts, one card per variant */
.fld-row.four { grid-template-columns: repeat(4, minmax(0, 1fr)); }
@media (max-width: 640px) { .fld-row.four { grid-template-columns: repeat(2, minmax(0, 1fr)); } }
.seg { display: flex; flex-wrap: wrap; gap: 8px 18px; }
#gSnps { display: grid; gap: 12px; }
.snp-card { padding: 12px; border: 1px solid var(--line); border-radius: 10px; background: var(--surface-2); display: grid; gap: 10px; }
.snp-card label { display: grid; gap: 3px; font-size: 13px; color: var(--ink-2); }
.snp-card input { min-height: 40px; padding: 0 10px; border: 1px solid var(--line-strong); border-radius: 8px; background: var(--surface); color: var(--ink); font: inherit; font-size: 14.5px; width: 100%; }
.snp-wrap { overflow-x: auto; }
.snp-g { border-collapse: collapse; width: 100%; min-width: 420px; font-size: 13.5px; }
.snp-g th { text-align: left; font-weight: 600; padding: 4px 6px; white-space: nowrap; }
.snp-g thead th { color: var(--ink-2); font-size: 13px; }
.snp-g td { padding: 3px 4px; }
.snp-g td input { min-width: 64px; }
.snp-act { display: flex; flex-wrap: wrap; gap: 6px 18px; }
.snp-act .del-snp { color: var(--bad); }
.gs-out { padding: 12px 14px; border-radius: 10px; background: var(--accent-soft); font-size: 14.5px; }